Multicentric Carpotarsal Osteolysis Mimicking Juvenile Idiopathic Arthritis

Remarkable improvement of articular pain by biologics in a Multicentric carpotarsal osteolysis patient with a mutation of MAFB gene.

Introduction Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare autosomal dominant disorder, characterized by aggressive osteolysis of the carpal and tarsal bone, and progressive nephropathy leading to end-stage renal disease. Recently, heterozygous mutations in MAFB gene within a short region of the amino-terminal transcriptional activation domain had been reported to cause MCTO. Al...

Idiopathic multicentric osteolysis with acro-osteolysis. A case report.

We report a case of multicentric massive osteolysis. A 52-year-old woman presented with a three-year history of progressive deformities of the hands. She had osteolytic lesions of the metacarpals and metatarsals, and resorption of the terminal phalanges. During follow-up over four years osteolysis spread to affect the ribs, clavicles, mandible, and long bones. There was no family history of any...

Osteoid osteoma of the scaphoid bone mimicking juvenile idiopathic arthritis

Results A 15 yo boy was referred to Rheumatology for left wrist swelling. His past medical history was unremarkable until 8 months prior when he began to have significant pain and progressive swelling of the left wrist. He was initially diagnosed with a fracture of the scaphoid bone for which he was casted for 2 months. After the cast was removed, the patient noticed that his symptoms persisted...

Idiopathic multicentric osteolysis: a case report and literature review.

Osteolysis is defined as destruction of bone by resorption. Usually this resorption is associated with some underlying disorder and classified as secondary osteolytic syndromes. Primary idiopathic osteolysis is rare. It is characterised by the spontaneous onset of bone resorption without known causative factors. Bones which previously appeared normal begin to undergo partial or complete resorpt...

Juvenile idiopathic arthritis.

Juvenile idiopathic arthritis (JIA), a term referring to a group of disorders characterized by chronic arthritis, is the most common chronic rheumatic illness in children and is a significant cause of short- and long-term disability. This article discusses the classification, differential diagnosis, and treatment of JIA.

Juvenile Idiopathic Arthritis